Yes!  Here are a few of the biggest differences:

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1.  Bumblebees are larger, rounder and fuzzier than honeybees, which are so slim they are sometimes mistaken for wasps.

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2.  Bumblebees are native to North America!  Honeybees, on the other hand, were brought here from Europe. 

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3.  There are more than 40 species of bumblebees in North America, but only 7 species of honeybees.

 

4.  Bumblebees are better pollinators!  Why?  First, bumblebees feed from a greater variety of flowers.  Second, they are larger than honeybees.  This means that a bumblebee can carry a larger amount of pollen.